Welcome to the Teacher's Website of Mr. Mokhtarzada
1. Peer-reviewed Scientific Journals
Biochemistry. 2011 Feb 8;50(5):715-26. doi: 10.1021/bi101236z. Epub 2011 Jan 14.
Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway.
Mokhtarzada S1, Yu C, Brickenden A, Choy WY.
J Neurosci. 2008 Nov 19;28(47):12570-80. doi: 10.1523/JNEUROSCI.4048-08.2008.
Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.
Seah C1, Levy MA, Jiang Y, Mokhtarzada S, Higgs DR, Gibbons RJ, Bérubé NG.
2. Abstracts at Symposiums, National, and International Conferences
2. Abstracts at Symposiums, National, and International Conferences
50th Experimental NMR Conference (ENC) [078] Pacific Grove, California, U.S.A
Structural Characterization of Intrinsically Disordered Chibby using NMR Spectroscopy and Its Mechanism of Interaction in Wnt Signaling
March 29 - April 3 2009
Authors:
Presented by:
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Sulayman Mokhtarzada
"In Wnt signaling, elevated levels of ß-catenin in the nucleus are associated with cancer. Here, we show the first structural characterization of human Chibby (via NMR), a 126 residue intrinsically disordered protein that is a direct inhibitor of ß-catenin in the nucleus. The N- terminal half of Chibby is predominantly unfolded. The C-terminal half of the protein contains some helical content, which is also a coiled-coil motif. Chibby uses these two halves independently of each other to bind to different targets, thereby acting as a hub in the signaling cascade. Preliminary NMR data evolving around the interaction of N-terminal Chibby with tumor suppressor protein 14-3-3 and of C-terminal Chibby with tumorigenic and natively disordered TC-1 are also presented."
3. Master of Science Thesis (M.Sc.)
Research Thesis: Structural Characterization of Intrinsically Disordered Human Chibby and its Interaction Mechanisms in the Wnt-signaling Pathway, Sulayman Mokhtarzada December 2009
4. 4th Year Honour's Thesis (h. B.Sc.)
Research Thesis: ATRX depletion may disrupt subcortical progenitor pools leading to subtype and layer- specific loss of GABAergic interneurons in the mouse forebrain, Sulayman Mokhtarzada April 2007
Nature of Science
'Science is a highly collaborative subject and many discoveries lie on the boundary between different disciplines often brought about as a result of collaboration between scientists of different nationalities and at universities in different countries. Scientists publish work in peer-reviewed journals, which make the knowledge available to other scientists.'
Excerpt taken from Chemistry for the IB Diploma, p. 147, 2nd Edition by Steve Owen, Cambridge University Press