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1. Peer-reviewed Scientific Journals
 2. Abstracts at Symposiums, National, and International Conferences
 2. Abstracts at Symposiums, National, and International Conferences

50th Experimental NMR Conference (ENC) [078] Pacific Grove, California, U.S.A

Structural Characterization of Intrinsically Disordered Chibby using NMR Spectroscopy and Its Mechanism of Interaction in Wnt Signaling

March 29 - April 3 2009


Presented by:

  • Sulayman Mokhtarzada

"In Wnt signaling, elevated levels of ß-catenin in the nucleus are associated with cancer. Here, we show the first structural characterization of human Chibby (via NMR), a 126 residue intrinsically disordered protein that is a direct inhibitor of ß-catenin in the nucleus. The N- terminal half of Chibby is predominantly unfolded. The C-terminal half of the protein contains some helical content, which is also a coiled-coil motif. Chibby uses these two halves independently of each other to bind to different targets, thereby acting as a hub in the signaling cascade. Preliminary NMR data evolving around the interaction of N-terminal Chibby with tumor suppressor protein 14-3-3 and of C-terminal Chibby with tumorigenic and natively disordered TC-1 are also presented."

3. Master of Science Thesis (M.Sc.)

Research Thesis: Structural Characterization of Intrinsically Disordered Human Chibby and its Interaction Mechanisms in the Wnt-signaling Pathway, Sulayman Mokhtarzada December 2009

4. 4th Year Honour's Thesis (h. B.Sc.)

Research Thesis: ATRX depletion may disrupt subcortical progenitor pools leading to subtype and layer- specific loss of GABAergic interneurons in the mouse forebrain, Sulayman Mokhtarzada April 2007

Nature of Science

'Science is a highly collaborative subject and many discoveries lie on the boundary between different disciplines often brought about as a result of collaboration between scientists of different nationalities and at universities in different countries. Scientists publish work in peer-reviewed journals, which make the knowledge available to other scientists.'

Excerpt taken from Chemistry for the IB Diploma, p. 147, 2nd Edition by Steve Owen, Cambridge University Press

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